Pitx1 determines characteristic hindlimb morphologies in cartilage micromass culture
نویسندگان
چکیده
منابع مشابه
Pitx1 determines characteristic hindlimb morphologies in cartilage micromass culture
The shapes of homologous skeletal elements in the vertebrate forelimb and hindlimb are distinct, with each element exquisitely adapted to their divergent functions. Many of the signals and signalling pathways responsible for patterning the developing limb bud are common to both forelimb and hindlimb. How disparate morphologies are generated from common signalling inputs during limb development ...
متن کاملPitx1 is necessary for normal initiation of hindlimb outgrowth through regulation of Tbx4 expression and shapes hindlimb morphologies via targeted growth control.
The forelimbs and hindlimbs of vertebrates are morphologically distinct. Pitx1, expressed in the hindlimb bud mesenchyme, is required for the formation of hindlimb characteristics and produces hindlimb-like morphologies when misexpressed in forelimbs. Pitx1 is also necessary for normal expression of Tbx4, a transcription factor required for normal hindlimb development. Despite the importance of...
متن کاملPitx1 and Pitx2 are required for development of hindlimb buds.
Two closely related homeobox transcription factors, Pitx1 and Pitx2, have been implicated in patterning of lateral plate mesoderm derivatives: Pitx1 for specification of hindlimb identity and Pitx2 for determination of laterality. We show that, together, Pitx1 and Pitx2 are required for formation of hindlimb buds and, when present in limited doses, for development of proximal (femur) and anteri...
متن کاملThe structure of Human Mesenchymal Stem Cells Differentiated into Cartilage in Micromass Culture System
Received: 25/Sep/2006, Accepted: 22/Nov/2006 Introduction: The aim of this study was to differentiate human mesenchymal stem cells (hMSCs) into cartilage in a micromass culture system and study of their structure by light and electron microscopy. Material and Methods: Human bone marrow cells obtained from volunteer patients were plated in 75-cm flasks and their MSCs were expanded through severa...
متن کاملthe structure of human mesenchymal stem cells differentiated into cartilage in micromass culture system
introduction: the aim of this study was to differentiate human mesenchymal stem cells (hmscs) into cartilage in a micromass culture system and study of their structure by light and electron microscopy. material and methods: human bone marrow cells obtained from volunteer patients were plated in 75-cm2 flasks and their mscs were expanded through several sub-cultures. the passage 4 cells were use...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0180453